Key Publications

Sun, X., Bernstein, M.J., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., David, D., Garcia-Dominquez, D., Hung, M., Meng, M., Rao, S., Sørensen, A.T., Yao, L., Zhang, X., Anikeeva, P.O. & Lin, Y. Functionally Distinct Neuronal Ensembles Within the Memory Engram. Cell, in press.

Weng, F.J., Garcia, R.I., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., David, D., Garcia-Dominquez, D., Hung, M., Yelhekar, T.D., Sørensen, A.T., Xu, W., Chung, K., Castillo, P. & Lin, Y. Npas4 is a Critical Regulator of Learning-induced Plasticity at Mossy Fiber-CA3 Synapses During Contextual Memory Formation. Neuron 97, 1137-1152 (2018).

Taniguchi, M., Carreira, M.B., Cooper, Y.A., Bobadilla, A., Heinsbroek, J.A., Koike, N., Larson, E.B., Balmuth, E.A., Hughes, B., Penrod, R.D., Kumar, J.,  Smith, L.N., Guzman, D.,  Takahashi, J.S., Kim, T.K., Self, D.W., Kalivas, P.W., Lin, Y., Cowan, C.W. HDAC5 and NPAS4 regulate cocaine addiction-relevant behaviors. Neuron 96, 130-144 (2017).

Sorensen, A.T., Cooper, Y.A., Baratta, M.V., Zhang, Y., Weng, F.J., Ramamoorthi, K., Fropf, R., LaVerriere, E., Xu, J., Young, A., Schneider, C., Gøtzsche, C.R., Hemberg, M., Yin, J.C.P., Maier, S.F. and Lin, Y. A robust activity marking system for exploring active neuronal ensembles. eLife 5, e13918 (2016). Download PDF

Sun, X.C. & Lin, Y. Npas4: Linking neuronal activity to neural circuit plasticity. Trends in Neurosciences 39, 264-75 (2016)Download PDF

Sim, S., Antolin, S., Lin, C.W., Lin, Y., and Lois C. Increased cell-intrinsic excitability induces synaptic changes in new neurons in the adult dentate gyrus that require Npas4. J. Neurosci. 33, 7928-40 (2013)Download PDF

Leong, W.K., Klaric, T.S., Lin, Y., Lewis, M.D., Koblar, S.A. Upregulation of the neuronal Per-Arnt-Sim domain protein 4 (Npas4) in the rat corticolimbic system following focal cerebral ischemia. Eur. J. Neurosci. 37, 1875-84 (2013).

Ramamoorthi, K., French R.A., Belfort G.M., Fitzmaurice H.L., McKinney R.M., Neve, R.L., Otto, T. & Lin, Y. Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation. Science 334, 1669-75 (2011).  Download PDF   Supplemental Information

Ramamoorthi, K. & Lin Y. The contribution of GABAergic dysfunction to neurodevelopmental disorders. Trends in Molecular Medicine 17, 452-62 (2011).  Download PDF

Lin, Y., Bloodgood, B.L., Hauser, J.L., Lapan, A.D., Koon, A.K., Kim, T.K., Hu, L.S., Malik, A.N. and Greenberg, M.E. Activity-dependent regulation of inhibitory synapse development by Npas4. Nature 455, 1198-1204 (2008).  Download PDF   Supplemental Information

Other Publications

Chen G., Zhang Y., Li X., Zhao X., Ye Q., Lin Y., Tao H.W., Rasch M.J. & Zhang X. Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations. Neuron 96, 1403-1418 (2017).

Crittenden, J.R., Lacey, C.J., Weng, F.J., Garrison, C.E., Gibson, D.J., Lin, Y., and Graybiel, A.M. Striatal Cholinergic Interneurons Modulate Spike-Timing in Striosomes and Matrix by an Amphetamine-Sensitive Mechanism. Front. Neuroanat. 11, 20 (2017).

Van Dort C.J., Zachs D.P.,.Kenny J.D., Zheng S., Goldblum R.R., Gelwan N.A., Ramos D.M., Nolan M.A., Wang K., Weng F.J., Lin Y., Wilson M.A., Brown E.N. Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc. Natl. Acad. Sci. U. S. A. 112, 584-9 (2014).

Chuong, A.S., Miri, M.L., Busskamp, V., Matthews, G.A.C, Acker, L.C., Sørensen, A.T., Young, A.N., Klapoetke, N.C., Henninger, M.A., Kodandaramaiah, S.B., Ogawa, M., Ramanlal, S.B., Forest, C.R., Chow, B.Y., Han, X., Lin, Y., Tye, K.M., Roska, B., Cardin, J.A., Boyden, E.S. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat. Neurosci. 17, 1123-9 (2014).

Ross, S.E., McCord, A.E., Jung, C., Atan, D., Mok, S.I., Hemberg, M., Kim, T.K., Salogiannis, J., Hu, L., Cohen, S., Lin, Y., Harrar, D., McInnes, R.R., Greenberg, M.E. Bhlhb5 and Prdm8 Form a Repressor Complex Involved in Neuronal Circuit Assembly. Neuron 73, 292-303 (2012).

Chow B.Y., Han X., Dobry A.S., Qian X., Chuong A.S., Li M., Henninger M.A., Belfort G.M., Lin Y., Monahan P.E. & Boyden, E.S. High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature 463, 98-102 (2010).

Morrow E.M., Yoo S.Y., Flavell S.W., Kim T.K., Lin Y., Hill R.S., Mukaddes N.M., Balkhy S., Gascon G., Hashmi A., Al-Saad S., Ware J., Joseph R.M., Greenblatt R., Gleason D., Ertelt J.A., Apse K.A., Bodell A., Partlow J.N., Barry B., Yao H., Markianos K., Ferland R.J., Greenberg M.E., Walsh C.A. Identifying autism loci and genes by tracing recent shared ancestry. Science 321, 218-223 (2008).

Paradis, S., Harrar, D.B., Lin, Y., Koon, A.K., Hauser, J.L., Griffith, E.C., Zhu, L., Brass, L.F., Chen, C. and Greenberg, M.E. An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. Neuron 53, 217-232 (2007).

Zhou, Z., Hong, E.J., Cohen, S., Zhao, W.N., Ho, H.Y., Schmidt, L., Chen, W.G., Lin, Y., Saver, E., Griffith, E.C., Hu, L., Steen, J.A., Weitz, C.J. and Greenberg, M.E. Brain-specific phosphorylation of MeCP2 regulates activity-dependent BDNF transcription, dendritic growth and spine maturation. Neuron 52, 255-269 (2006).

Flavell, S.W., Cowan, C.W., Kim, T.K., Greer, P.L., Lin, Y., Paradis, S., Griffith, E.C., Hu, L.S., Chen, C. and Greenberg, M.E. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311, 1008-1012 (2006).

Brunet, A., Sweeney, L.B., Sturgill, J.F., Chua, K.F., Greer, P.L., Lin, Y., Tran, H., Ross, S.E., Mostoslavsky, R., Cohen, H.Y., Hu, L.S., Cheng, H.L., Jedrychowski, M.P., Gygi, S.P., Sinclair, D.A., Alt, F.W. and Greenberg, M.E. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015 (2004).

Chen, W.G., Chang, Q., Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R. and Greenberg, M.E. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302, 885-889 (2003).

Lin, Y., Dötsch, V., Wintner, T., Peariso, K., Myers, L.C., Penner-Hahn, J.E., Verdine, G.L. and Wagner, G. Structural basis for the functional switch of the E. coli Ada protein. Biochemistry 40, 4261-4271 (2001).

Luo, X., Fang, G., Goldiron, M., Lin, Y., Yu, H., Kirschner, M.W. and Wagner, G. Structure and interaction with CDC20 of the spindle assembly checkpoint protein Mad2. Nature Struct. Biol. 7, 224-229 (2000).

Lin, Y. and Wagner, G. Efficient sidechain and backbone assignment in large proteins: Application to tGCN5. J. Biomol. NMR 15, 227-239 (1999).

Lin, Y., Fletcher, C.M., Zhou, J., Allis, C.D. and Wagner, G. Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A. Nature 400, 86-89 (1999).